India has recently introduced Qartemi, the country's first internationally approved CAR-T cell therapy designed for treating adult B-cell Non-Hodgkin Lymphoma (B-NHL). This innovative therapy brings renewed hope to patients battling aggressive blood cancers.
About CAR-T Therapy
CAR-T (Chimeric Antigen Receptor T-cell) therapy is a form of immunotherapy that enhances the body's immune system to fight cancer. It involves altering a patient’s T-cells to make them more capable of targeting and attacking cancer cells. The process includes extracting T-cells from the patient, modifying them in the lab, and then reintroducing them into the patient’s body, effectively creating a “living drug.”
Clinical Trials And Effectiveness
The effectiveness of Qartemi has been evaluated in the IMAGINE trial, which was conducted across several hospitals including Narayana Hospital and Apollo Cancer Hospital. In its Phase 2 trial, Qartemi demonstrated an overall response rate (ORR) of 83.3%, which is considered significantly effective when compared to global standards.
Addressing Blood Cancer In India
India is seeing an increasing incidence of blood cancers, with approximately 120,000 new cases reported every year. Qartemi offers a promising treatment option for patients with relapsed or refractory B-NHL, providing a new avenue for those who have not responded to conventional treatments.
Transforming Cancer Treatment
The approval of Qartemi is considered a major advancement in personalized medicine. It merges cutting-edge research with local manufacturing, potentially reshaping the landscape of cancer care in India and setting new benchmarks for treatment.
Understanding Non-Hodgkin Lymphoma (NHL)
Non-Hodgkin Lymphoma (NHL) is a cancer of the lymphatic system, which is an essential part of the immune system. The lymphatic system comprises organs, glands, vessels, and lymph nodes that help combat infections. NHL occurs when the immune cells in the lymphatic system grow uncontrollably, leading to tumor formation. There are various subtypes of NHL, including Diffuse Large B-cell Lymphoma (DLBCL) and Follicular Lymphoma. It is important to distinguish NHL from Hodgkin Lymphoma, which is another major type of lymphoma.
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