Description

Recent research has shown that nano-traps can bind to SARS-CoV-2 viruses and neutralize them. Nano-traps are made from human lung spheroid cells (LSC). It promotes viral clearance and reduces lung damage in model monkeys of COVID-19.

Nano-bait therapy can be effective against emerging variants of the coronavirus by mimicking the receptor that the coronavirus binds to, rather than targeting it.

How will this therapy work?

SARS-CoV-2 enters the cell when its spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor on the cell surface. LSCs, which are a natural mixture of lung epithelial stem cells and mesenchymal cells, also express ACE2. This makes the LSC the perfect tool to cheat on the coronavirus.

How was the testing done?

The scientists confirmed that the spike protein did indeed bind to ACE2 receptors in traps in vitro. They then used the manufactured SARS-CoV-2 simulator for in vivo testing in a mouse model. Traps were delivered using inhalation therapy. In mice, nano-traps remained in the lungs for 72 hours after the first dose and accelerated clearance of the mimic virus.

Nano-baits are cellular ghosts. One LSC can create about 11,000 nano-traps. When these nano-traps are used, they exponentially increase the area of ??the fake binding sites to trap the virus.

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